🎉 Join our fertility webinar on the 12th of March! Register now
Preimplantation Genetic Testing
PGT-SR
If you or your partner are known to have a structural chromosome abnormality, embryos can be specifically tested for this using ICSI with PGT-SR. Our doctors will advise you individually on your options.
:quality(75))
No long waiting times
In-house lab
Holistic care
Transparent costs
What is PGT-SR?
PGT-SR (Preimplantation Genetic Testing for Structural Rearrangements) is a procedure in which embryos are specifically examined for structural chromosome changes. For this purpose, a small cell sample is taken from the embryo and analysed in the laboratory. Only embryos with a normal chromosome distribution are selected for transfer to the uterus.
Good to know: Unlike PGT-M, PGT-SR does not search for a specific gene mutation, but rather for changes in the structure of the chromosomes, such as translocations or inversions. PGT-SR is particularly relevant if such a change has already been diagnosed in one of the parents.
What chromosomal abnormalities can PGT-SR detect?
Structural chromosome changes can increase the risk of miscarriage or the birth of a child with a disability.
Reciprocal translocation
Two chromosomes have exchanged sections with each other. Carriers are usually healthy, but have an increased risk of miscarriage or chromosomal abnormalities in their child.
Robertson translocation
Two specific chromosomes are fused together. Here too, carriers are usually symptom-free, but the risk of miscarriage or chromosomal abnormalities in the child is increased.
Inversions
A section within a chromosome is inverted. Carriers have no symptoms, but reproduction may result in miscarriages or chromosomal abnormalities in the child.
:quality(100))
:quality(100))
When is PGT-SR the right decision?
If you have experienced repeated miscarriages or are aware of a structural chromosome abnormality, PGT-SR may be a sensible option. This test allows embryos with normal chromosome distribution to be selected for transfer, thereby increasing the chances of a successful pregnancy. We will discuss whether PGT-SR is appropriate in your situation during a genetic consultation.
:quality(75))
Preimplantation Genetic Testing (PGT)
How does PGT-SR differ from PGT-A and PGT-M?
:quality(75))
PGT-A checks whether an embryo has the correct number of chromosomes and detects random abnormalities such as trisomy 21. PGT-M specifically searches for a particular gene mutation that is known to run in the family. PGT-SR examines whether the structure of the chromosomes is correct and is used when a structural change has been diagnosed in one of the parents.
:quality(75))
PGT-SR: Step-by-Step
After egg retrieval and fertilisation using ICSI, the embryos are cultured for five to six days. This is followed by a biopsy, before samples are cryopreserved and sent to our partner laboratory for genetic analysis. We then discuss the results and plan the next steps.
Step 1
Genetic Counseling
Your family medical history will be recorded during a detailed genetic consultation. Based on this, the genetic analysis will be individually tailored to the known mutation in your family. In addition, approval will be sought from the ethics committee.
Step 2
ICSI and Embryo Biopsy
After hormonal stimulation, the eggs are retrieved and fertilised in the laboratory (IVF or ICSI). The embryos are cultured, and on the third or fifth day, individual cells are retrieved for genetic testing.
Step 3
Genetic Analysis
The cells taken are examined in the laboratory for genetic characteristics. The results of the genetic analysis are evaluated and interpreted.
Step 4
Embryo Transfer
Based on the results, an embryo without the relevant mutation is selected for transfer and placed in the uterus. Other healthy embryos can be frozen for later use.
Step 5
Pregnancy Test
A pregnancy test is carried out approximately two weeks after the embryo transfer. If you are pregnant, further examinations may be recommended.
Your specialists at Cada
Our experienced doctors specialise in modern reproductive medicine and will accompany you every step of the way.
:quality(75))
:quality(75))
:quality(75))
:quality(75))
:quality(75))
:quality(75))
:quality(75))
Further genetic testing
PGT-SR is one of several genetic procedures that can be used in fertility treatment. Find out more about other options here.
Our Location
Our Clinic in Zurich
At the modern Cada Clinic, located directly on Lake Zurich, you'll find fertility treatments such as IVF, ICSI, and social freezing.
All experts in one place
Peaceful location in Zurich Seefeld
On-site IVF laboratory
:quality(75))
:quality(75))
:quality(75))
We’re happy to answer your questions
:quality(75))
Frequently Asked Questions (FAQ)
Discover answers to the most common queries about PGT-SR here. Should your question remain unresolved, please do not hesitate to reach out to us directly.
Is PGT-SR permitted in Switzerland?
Yes. Pre-implantation genetic testing has been legally permitted in Switzerland since September 2017. For PGT-SR, the approval of an ethics committee is also required. At Cada, we guide you through the entire application process.
In Germany, PGT-SR is also possible in principle, but is subject to much stricter restrictions. The Embryo Protection Act of 1990 is one of the most restrictive regulations in Europe and limits, among other things, the number of eggs that may be fertilised per cycle. This can reduce the chances of having enough embryos for meaningful genetic testing. In addition, PGT-SR may only be performed in a few specially approved centres in Germany. These restrictions do not exist in Switzerland, which allows for more flexibility in treatment.
How does PGT-SR differ from PGT-A?
PGT-A checks whether an embryo has the correct number of chromosomes and detects random abnormalities such as trisomy 21. PGT-SR specifically examines whether the structure of the chromosomes is correct and is used when a structural change has been diagnosed in one of the parents.
How long does the entire PGT-SR process take?
The process begins with genetic counselling and an application to the ethics committee. This is followed by the IVF/ICSI cycle, embryo biopsy and genetic analysis. You should allow several weeks from the initial consultation to the embryo transfer.
At Cada, we do everything we can to make the process as efficient as possible and reduce waiting times to a minimum. We therefore recommend that you start the assessment process early so that no valuable time is lost.
Does the biopsy harm the embryo?
The biopsy is performed on the fifth or sixth day of development, when the embryo consists of several hundred cells. Only a few cells are removed from the outer cell layer, which later forms the placenta. According to current knowledge, the biopsy has no negative impact on the development of the embryo.
Are the costs of PGT-SR covered by health insurance?
In Switzerland, the costs for PGT-SR are not usually covered by basic insurance. Genetic analysis and IVF/ICSI treatment are services that must be paid for out of pocket. We will provide you with transparent information about all costs incurred during the consultation. Flexible payment plans are also available.
Is ICSI mandatory for PGT-SR?
Yes. ICSI is required for PGT-SR to avoid contamination of the cell sample by excess sperm and to ensure a clear genetic result.
What happens if no embryo has normal findings?
This can happen, especially if only a few embryos are available. In this case, we will discuss further options with you, such as repeating the treatment cycle. Our doctors will advise you individually to find the best possible solution.
Does PGT-SR replace prenatal diagnostics during pregnancy?
No. PGT-SR can significantly reduce the risk of a pregnancy with an unbalanced chromosomal abnormality, but it does not replace regular prenatal diagnostics. Even after a normal PGT-SR result, the usual prenatal check-ups are recommended during pregnancy.
Schedule your consultation now
During a free initial consultation, we take the time to comprehend your needs and offer informed advice on your available options.
:quality(75))